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Highlighted Topic: The Missing Middle: Perimenopause as an Understudied Life Stage

National Institutes of Health

Perimenopause, or the menopausal transition, is a near-universal midlife event in women, yet it remains a systematic blind spot in research. Studies tend to enroll women who are clearly premenopausal or clearly postmenopausal and skip the variable, symptomatic window in between, leaving the transition itself poorly characterized. For perimenopause, its basic biology, its wide heterogeneity in onset, duration, and symptom burden, and the tools used to stage it are all underdeveloped. This heterogeneity includes populations of special interest in which the transition occurs earlier or is accelerated, such as people with Down syndrome and other intellectual and developmental disabilities. Compounding this, care during the transition is guided largely by age-based conventions and expert opinion rather than robust evidence.

Perimenopause is also not a single-system event. The hormonal shifts that define the transition to menopause have consequences across reproductive, skeletal, cardiometabolic, cognitive, and mental health domains, and several of these changes, including bone loss, begin during the transition rather than after menopause. Yet, because the window is so often skipped in studies, the transition-specific evidence base for conditions otherwise well-studied in younger or postmenopausal women is sparse. Understanding perimenopause as a life stage on its own terms and distinguishing the effects of the transition from those of chronological aging is essential to improving health and function in the decades that follow.

This topic encourages investigator-initiated research that treats perimenopause as a distinct life stage warranting its own evidence base. Applications may address any area in which a transition-focused framing advances the science, and there is no expectation that a project will span multiple systems.

Apply through an appropriate NIH Parent Funding Announcement or another broad NIH opportunity available on Grants.gov .

Expiration Date: October 19, 2028

Specialties

Medical

Medical - Clinical Science

Medical - Basic Science

Medical - Translational

Eligibility Requirements

Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Sponsor Type: Government/Federal

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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