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Global Grand Challenges: Estimating the Global Burden of Diarrheal Diseases

Gates (Bill & Melinda) Foundation

The Gates Foundation invites proposals to generate independent, policy-relevant estimates of the global burden of diarrheal diseases, with a focus on mortality and morbidity in children under five living in low- and middle-income countries (LMICs).

Reliable burden estimates are essential for prioritizing disease syndromes and pathogens and for guiding investments in prevention, treatment, and product development. However, estimating diarrheal mortality and morbidity and pathogen-specific burden remains challenging because direct mortality and morbidity data are limited in many LMIC settings, etiologic data are uneven and often derived from studies of cases rather than deaths, and attribution methods must reconcile imperfect diagnostics, multiple pathogens, incomplete surveillance, and sparse location-specific evidence. Modelled estimates of global burden of disease can help overcome data sparsity, and multiple independent estimates would be valuable for triangulating estimates of burden and understanding key drivers of differences. Differences across existing estimates may arise from variation in data inputs, mortality envelopes, etiologic attribution methods, model structure, and assumptions.

The Foundation seeks to support independent estimation efforts that inform the overall burden of diarrhea and pathogen-specific contributions, clarify key sources of uncertainty, and produce decision-useful estimates for policymakers, researchers, and global health partners.

Deadline: June 16, 2026

Specialties

International Opportunities

Medical - Clinical Science

Medical

Social Sciences

Eligibility Requirements

This opportunity is open to research institutes, nonprofit organizations, for-profit companies, international organizations, government agencies, and academic institutions. with demonstrated expertise in disease burden estimation, epidemiology, biostatistics, and related quantitative methods.

We welcome proposals from:

LMIC-based institutions
Partnerships led by LMIC institutions
Global consortia that include meaningful LMIC partner engagement and capacity development

Sponsor Details

Sponsor Institute/Organizations: Gates (Bill & Melinda) Foundation

Sponsor Type:

Address: 2099 Pennsylvania Ave, NW Suite 200 Washington DC 20006 USA

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