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Accelerating Discovery through Partnered Research with All of Us to Analyze Participant Biospecimens (X01 Clinical Trial Not Allowed)

National Institutes of Health

The purpose of this Program Announcement with Special Receipt, Referral, and/or Review Considerations (PAR) is to solicit applications to access stored blood plasma, blood serum, and extracted DNA from the All of Us Research Program supported Biobank to advance the program'smission of accelerating health research and medical breakthroughs, enabling individualized prevention, treatment, and care for all of us.

All of Us partnered research studies are collaborative initiatives funded by a study sponsor external to All of Us to collect and add new data to the All of Us Researcher Workbench in accordance with All of Us’ best practices. All of Us partnered research studies are open to the broad scientific community and require investigators to apply for and receive an X01 award under this announcement.

This will enable longitudinal followup and repeat sampling, and provide multiomic data (genomics, proteomics, metabolomics, and other highdimensional molecular profiles), integrated clinical, environmental, and lifecourse data, infrastructure designed to support future clinicaltrial recruitment, and publicprivate partnership pathways.

This opportunity will enable researchers to conduct assays to evaluate associations between newly collected and existing All of Us data and add new data to the All of Us dataset for broad use by the research community. High-priority areas for biospecimen analyses may include, but are not limited to, large scale projects that propose integrated multiomics analyses, early disease detection, biomarker discovery or validation, novel risk models for incident disease, and/or novel disease stratification for chronic disease risk, diagnosis, and prognosis, in support of advancing precision medicine. For more information, please visit the All of Us X01 Partnered Research Studies Resource webpage .

Application Due Date(s)

New (Resubmissions Not Applicable): July 1, 2026

New and Resubmissions: October 30, 2026

New and Resubmissions: March 1, 2027

PAR-27-069 Expiration Date: March 02, 2027

Specialties

Medical

Medical - Clinical Science

Medical - Basic Science

Eligibility Requirements

Sponsor Details

Sponsor Institute/Organizations: National Institutes of Health

Sponsor Type: Government/Federal

Address: National Institutes of Health; 31 Center Drive; MSC 2220; Bethesda; MD 20892-2220; USA

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