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CRI Immuno-Informatics Postdoctoral Fellowship

Cancer Research Institute

The CRI Immuno-Informatics Postdoctoral Fellowship Program supports outstanding early-career scientists worldwide who seek dual expertise in immunology and data science. This unique program fosters a new generation of researchers fluent in both biology and computation, equipping them to drive innovation in cancer immunotherapy.

Focus and Scope

Cancer immunology is increasingly reliant on scientists who can bridge the biological and quantitative sciences. The integration of immunology with computational biology, data science, and genomics represents a critical frontier for advancing the discovery and development of novel immune-based therapies.

The CRI Immuno-Informatics Fellowship is designed to support:

Computational biologists seeking to deepen their understanding of immunology
Cancer immunologists aiming to gain expertise in computational biology, data science, and/or genomics
Researchers from diverse PhD backgrounds pursuing training at the interface of cancer immunology and computational biology

Eligible projects must be hypothesis-driven in basic or translational cancer immunology and should:

Demonstrate the potential to advance understanding of the immune system’s role in cancer
Leverage innovative technologies or computational methods, including high throughput “omic” approaches and advanced data analyses
Clearly articulate how the work addresses critical gaps in cancer immunology

Financial Support

Fellowships provide three years of support, including a stipend of $74,000, $76,000, and $78,000 in years 1-3. The host institution receives a $5,000 annual allowance for use at the sponsor’s discretion to cover costs such as research supplies, conference travel, health insurance, or childcare. CRI also provides dedicated support for fellows to attend the CRI Bioinformatics Bootcamp. Deductions for administrative overhead are not allowed from either the stipend or the institutional allowance.

Deadlines

The application deadlines are March 1 and September 1 annually; when those dates fall on the weekend or holiday, applications are due the following workday. Applications are due by 11:59 p.m. Eastern Time on these dates. Applicants are notified of fellowship committee decisions within approximately 10-12 weeks of the application deadline.

Fellowships can be activated 4 months after the application deadline but no later than 1 year following the deadline. Awards activate on the first of the month.

AI Based Application Success Predictor

1. Direct relevance to cancer immunology and immunotherapy (highest predictor)

This is the most important predictor.

CRI is not a general cancer-research funder. Competitive projects should directly advance understanding or application of:

Tumor immunology
Fundamental immunology relevant to cancer
Immune-cell function in tumors
Cancer immunotherapy
Immune resistance and response
Tumor microenvironment
Immunological biomarkers
Immune-based therapeutic strategies

For the Irvington Postdoctoral Fellowship, CRI specifically emphasizes hypothesis-driven, mechanistic research in fundamental immunology and tumor immunology, including how the work will advance understanding of the immune system's role in cancer.

2. Scientific significance, innovation, and feasibility (very high predictor)

CRI explicitly identifies three core proposal-review dimensions:

Significance
Innovation
Feasibility

The strongest applications address an important immunological problem, introduce a genuinely new concept or approach, and remain technically achievable. Ambitious science is attractive, but the experimental strategy must still be convincing.

3. Strong candidate qualifications and demonstrated track record (very high predictor)

CRI formally considers:

Candidate qualifications
Demonstrated research track record
Evidence of scientific productivity
Technical expertise
Potential for future impact

For trainee and career-development programs, reviewers assess accomplishments relative to career stage rather than simply rewarding the longest publication list.

4. Potential to become a future leader in cancer immunology

Investigator development is central to CRI's funding model. Its programs span early-career researchers through established investigators and are designed to cultivate scientific leaders who can advance cancer immunotherapy.

Strong indicators include:

Clear long-term research vision
Commitment to immunology or tumor immunology
Emerging scientific independence
Leadership potential
Ability to establish a distinctive research direction

5. Outstanding sponsor, mentorship, and training environment (especially important for fellowships)

For postdoctoral funding, CRI explicitly reviews both:

The strength of the sponsor
The quality of the training environment

Competitive applications typically demonstrate access to expert mentorship, strong immunology infrastructure, appropriate technologies, and an environment capable of advancing the fellow toward independence.

6. Acquisition of genuinely new skills and expertise

A strong fellowship application explains how the proposed work will expand the applicant's capabilities through:

New experimental techniques
New conceptual expertise
Computational or data-science training
Advanced immunological methods
Cross-disciplinary mentorship

CRI expects the training experience to prepare the applicant for future scientific leadership and independence.

7. Bold, high-risk/high-reward potential (program-specific but very important)

Several CRI programs explicitly support bold ideas. The Lloyd J. Old STAR Program, for example, supports mid-career scientists pursuing high-risk, high-reward research at the leading edge of cancer immunotherapy, while the Technology Impact Award targets early-stage concepts with transformative potential.

The strongest proposals may challenge existing assumptions, open a new research direction, or create a technology that changes what is scientifically possible.

8. Strong translational pathway and clinical impact (for translational and clinical awards)

For programs such as the Clinic and Laboratory Integration Program and Clinical Innovator awards, success depends heavily on a credible bridge between immunological discovery and patient care. CRI's current portfolio explicitly supports research at the intersection of laboratory discovery and clinical application, as well as pioneering academic immunotherapy trials.

Competitive projects often demonstrate:

Strong biological rationale
Relevant biomarkers
Patient-selection strategy
Translational endpoints
Clinical-development potential
A realistic pathway toward testing or implementation

9. Interdisciplinary expertise and collaboration

Modern immunotherapy research often requires integration of:

Immunology
Oncology
Computational biology
Data science
Genomics
Bioengineering
Clinical research

CRI's current programs explicitly include opportunities at the intersection of immunology and data science, reinforcing the value of complementary expertise when it is essential to the scientific question.

Specialties

Cancer

Immunology

Data Science

Oncology

Eligibility Requirements

Applicants must have a doctoral degree by the date of award activation and must conduct their proposed research under a sponsor who holds a formal appointment as an assistant professor or higher rank at the host institution.
Applicants must be working in areas directly related to immunology or cancer immunology. An eligible project must fall into the broad field of immunology with relevance to solving the cancer problem.
Applicants who will have 5 or more years of mentored research experience at the time of award activation are not eligible, with the exception of M.D. applicants, who should not include years of residency in this calculation. Applicants should use their doctoral degree conferral date when calculating eligibility.
Only in exceptional circumstances will applicants who have already spent 3 or more years in a sponsor’s laboratory by the start date of fellowship be considered for a fellowship award.
The fellowship can be performed in the United States or abroad but must take place at a non-profit institution. There are no citizenship restrictions.
Only 1 fellow per sponsor may apply per application round, and faculty sponsors may not have more than 3 CRI-supported fellows at any time.
Resubmissions: Applicants are permitted to resubmit their fellowship application at a subsequent deadline provided that the new application is improved to reflect progress. Changes to the application should be addressed within the subsequent application.

Sponsor Details

Sponsor Institute/Organizations: Cancer Research Institute

Sponsor Type: Corporate/Non-Profit

Address: 29 Broadway, Floor 4  New York, NY 10006-3111

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