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Capacity Building in International Dementia Research Program

Alzheimer's Association

This funding mechanism is sponsored by the Alzheimer’s Association and Global Brain Health Institute (GBHI) at the University of California, San Francisco. We explicitly target capacity building for scientific investigation within institutions located in Low- and Middle-Income countries (LMIC) where prior research funding has been received, but barriers for sustainability exist.

Program overview

Potential applicants are encouraged to consider proposals that would fill current gaps in their research infrastructure and enable them to build larger and more sustainable portfolios, including but not limited to:

Developing or expanding training programs
Creating or adapting culturally appropriate research tools
Collecting normative data
Engaging in community outreach activities to raise awareness and bolster recruitment
Supporting personnel who enable sustainable research including statisticians, laboratory managers, technicians, research administrators, and database analysts
Building research databases
Arranging for investigators to have protected time for research
Organizing workshops around specific research skills such as grant writing and statistical methods
Providing translation and proof-reading services
Coordinating training and workshops for institutional personnel in topics that bolster research infrastructure, such as grant submission, research administration and laboratory skills

Applications for traditional research studies (e.g., observational or experimental studies) are not appropriate for this program. This mechanism is also not intended to fund construction/renovation of facilities or the purchase of major equipment (above a unit price of US$10,000).

Key dates

LOI and application submissions must be received by 5 p.m. ET by their respective deadlines. Late submissions will not be accepted - no exceptions.

Letter of Intent due: June 3, 2026 – 5 p.m. ET
Full application due: Sept. 2, 2026 – 5 p.m. ET
Award notifications: Dec. 2026

Funding overview

Budgets should typically not exceed $250,000 in total costs (direct and indirect) per year, with total costs for all years not to exceed $1,000,000.
The award duration should be aligned with the scope of the proposal with a minimum duration of three years and a maximum duration of five years with evidence of sustainability built into later years.
Please see the RFA for more information on allowed costs.

Application process

Letters of intent are required. More information can be found in the RFA and on ProposalCentral.
Full applications must be submitted through ProposalCentral.

Application review process

Please see “how to apply” for more information about the Alzheimer’s Association application review process. Details are also available in the RFA.

Additional information

For more information on eligibility, application requirements, review criteria, and more, please see the RFA.
All applicants/institutions are strongly encouraged to review the Conditions of Award (PDF) before submitting an LOI.

AI Based Application Success Predictor

🧠 1. Strong Focus on Alzheimer’s Disease & Related Dementias (Non-Negotiable)

Projects must directly address:
- Alzheimer’s disease (AD) or:
- Alzheimer’s disease and related dementias (ADRD)
Includes:
- Diagnosis
- Prevention
- Treatment
- Care and quality of life

👉 Non-dementia neuroscience → low success probability

🔄 2. Strong Translational Pathway (Top Predictor)

The Association funds:
- Basic science → translational → clinical → care research
Increasing emphasis on:
- Translational research and clinical interventions

👉 Key question:
“How will this improve diagnosis, prevention, treatment, or patient care?”

🎯 3. Clear Clinical or Patient Impact (Critical)

Successful proposals usually:

Improve:
- Early diagnosis
- Therapeutic strategies
- Dementia care
- Prevention approaches

👉 Patient benefit is a major scoring factor

🚀 4. Innovation & High-Risk, High-Reward Science

The Alzheimer’s Association actively funds:
- Novel and breakthrough ideas
Especially through:
- Part the Cloud (PTC) initiatives for translational trials

👉 Incremental proposals are less competitive

🧬 5. High Priority Areas: Biomarkers, Early Detection & Therapeutics

Frequently funded areas:

Blood-based biomarkers
Neuroimaging
Precision medicine
Disease-modifying therapies
Early prediction models

👉 Early detection and therapeutic development are especially competitive

👩‍🔬 6. Early-Career Investigator Development (Major Priority)

The Association strongly supports:
- Postdocs
- Junior faculty
- New investigators entering dementia research

👉 Career development potential is heavily weighted

🤝 7. Strong Mentorship & Research Environment

Fellowship and early-career awards require:
- Structured mentorship
- Institutional support
Strong mentors improve competitiveness substantially

🌍 8. Broad Research Scope Including Care & Health Equity

Unlike some neurodegeneration funders, the Alzheimer’s Association funds:

Social-behavioral research
Care interventions
Public health and prevention
Health equity studies

👉 Community and caregiving research can be highly competitive if impactful

🧪 9. Feasible, Well-Designed Pilot Research

Many awards are:
- Pilot or career-development grants
Strong proposals include:
- Clear aims
- Realistic timelines
- Preliminary rationale

👉 Overly ambitious projects are commonly rejected

📈 10. Potential for Future NIH or Major Funding

Alzheimer’s Association grants are often:
- Seed funding mechanisms
Strong proposals:
- Generate pilot data for:
  - NIH R01s
  - Clinical trials
  - Large consortium grants

🌐 11. International & Collaborative Research Advantage

The program is:
- International in scope
Encourages:
- Cross-institutional and multidisciplinary collaboration

👉 Collaboration strengthens competitiveness, especially for translational projects

📊 Summary: Key Predictors (Ranked)

🔥 Highest impact factors:

Alzheimer’s/ADRD-specific focus
Translational relevance
Clear patient or clinical impact

⚖️ Major differentiators:

Innovation/high-risk ideas
Biomarker or therapeutic relevance
Early-career investigator development

📌 Supporting factors:

Mentorship quality
Feasibility
Future funding potential
Collaboration

💡 Insider Insight

Compared to NIH:

Alzheimer's Association is:
👉 more willing to fund:
- Early-stage ideas
- Pilot studies
- High-risk concepts
Strongly focused on:
- Career development
- Translational impact

👉 Winning formula:
Innovative AD-focused project + translational pathway + strong mentorship + feasible pilot design

✔️ What wins:

Biomarker and early detection studies
Translational therapeutic research
Innovative pilot projects with clinical potential
Care and health equity interventions with measurable impact

❌ What struggles:

Non-AD neuroscience
Pure basic science without translational relevance
Weak clinical significance
Overly broad or unrealistic proposals

Specialties

Neurosciences

Eligibility Requirements

This opportunity is currently open to institutions / organizations in LMIC. See our full list of eligible countries (PDF).
The Project Lead must be a full-time faculty member or full-time paid employee of the organization submitting the proposal.
It is expected that for applications from more senior level faculty that there is a plan to engage and develop junior faculty members through this support.
The Project Lead or other key personnel at the institution/organization must have active or recently completed research funding upon which this proposal builds.
Investigators who have previously received Alzheimer’s Association funding and are currently delinquent in submitting required reports or have awards closed as “Incomplete” or “early termination” are not eligible to apply.

Sponsor Details

Sponsor Institute/Organizations: Alzheimer's Association

Sponsor Type: Corporate/Non-Profit

Address: 225 N Michigan Ave. Floor 17 Chicago, IL 60601 800.272.3900

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