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Call for Research Proposals

Angelman Syndrome Foundation, Inc.

ASF accepts research proposals on a continual basis, with annual submission deadlines for review on August 15th.

ASF Research Grant Review & Award Timeline

Application Opens on July 17, 2025

August 15 – Proposal Submission Deadline

Researchers must submit their grant applications by this date.

August – October – Scientific Review & Scoring

Proposals undergo peer review by independent scientific experts.
Each proposal is evaluated based on scientific merit, feasibility, and impact.

November – SAC & Board Review

The Scientific Advisory Committee (SAC) and ASF Board review scores and recommendations.
Applicants receive official notification of their funding status.

January – Funding is Dispersed

AI Based Application Success Predictor

🎯 1. Align with ASF’s Research Priorities

Funded proposals consistently match ASF’s Research Roadmap pillars — namely:

Regulating and restoring UBE3A function, including gene therapy, ASO, or CRISPR approaches.

Developing cutting-edge therapeutic strategies and delivery systems.

Investigating clinical care and symptom management (e.g., seizures, sleep, motor skills).

Defining validated endpoints and biomarkers for trials .

Priority topics include:

Correcting non-UBE3A gene effects in deletion cases.

Boosting UBE3A after therapeutic intervention.

Enhancing delivery approaches.

Enabling symptomatic relief and quality-of-life improvements .

🎯 2. Focus on Pilot-Stage, High-Potential Projects

ASF awards are designed as pilot funding, capped at $100K/year for up to 2 years.

They prefer high-risk, high-reward concepts (e.g., CRISPR, ASOs, novel gene therapies) while also supporting mechanistic or clinical-impact studies that can pave the way to larger funding .

ASF reports an average 17× leverage—every ASF dollar leads to ~$17 NIH funding .

🧪 3. Rigorous Peer Review & Resubmission Potential

Applications are reviewed by the Scientific Advisory Committee through a structured peer-review process; feedback is provided.

Proposals may be revised and resubmitted, so strong initial submissions with clear scientific merit stand out.

📝 4. Strong Proposal Structure & Substantive Content

Submit a single PDF (cover, abstract, hypothesis, methods, significance, biosketch, budget) by August 15 (also April/Oct deadlines depending on cycle) 

Use ASF’s template and adhere strictly to page limits, formatting rules, and budget guidelines (maximum 10% indirect costs) 

📊 5. Feasibility Demonstrated with Milestones & Preliminary Data

Include a realistic timeline and milestones for the 1–2 year grant period.

Provide preliminary proof-of-concept data or strong rationale supporting feasibility, especially for high-risk strategies .

💡 6. Plan for Leveraging Funding

Demonstrate how ASF support will unlock larger funding opportunities (e.g., NIH, foundations, pharma) .

🌍 7. Global & Multidisciplinary Collaboration

While U.S.-based PIs are common, ASF considers worldwide applicants, especially those forming multidisciplinary teams that enhance translational potential .

✅ Summary Table

Predictor	What to Do
Mission alignment	Tie project to ASF’s roadmap: UBE3A, delivery, symptomatic therapy, biomarkers
Pilot/innovative focus	Emphasize novel, high-risk, feasible studies
Peer-review readiness	Prepare to revise LOI/full proposal with feedback
Submission compliance	Strictly follow PDF format, deadlines, templates
Feasibility & milestones	Include preliminary data, clear timeline within 2 years
Leverage strategy	Show how ASF momentum leads to bigger funding
Collaborative framing	Build multidisciplinary, potentially international partnerships

💡 Pro Tips for Competitive Applications

Start with ASF’s Research Roadmap—make your aims directly map to one of the pillars 

Highlight novelty and disease relevance—use crisp language to describe the innovation and its translational pathway.

Ensure feasibility—include pilot data or a strong rationale; use clear milestones aligned with funding duration.

Budget succinctly—use direct cost only, max 10% indirect; show how external funding can build on ASF’s support.

Prepare for resubmission—integrate SAC feedback to improve chances on second submission.

Connect with ASF staff early if uncertain about fit or approach, especially for high-risk therapeutic projects.

Specialties

Clinical Trials

Others

Neurosciences

Eligibility Requirements

Researchers, clinicians, and institutions focused on advancing Angelman syndrome research

Sponsor Details

Sponsor Institute/Organizations: Angelman Syndrome Foundation, Inc.

Sponsor Type: Corporate/Non-Profit

Address: 3015 E. New York Street, Suite A2 #285, Aurora, IL 60504

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