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Bi-Annual Grant

Alzheimer's Foundation of America

Our Bi-Annual membership grants deliver funding for programs and services that help further AFA’s mission of providing support, services and education to individuals, families and caregivers affected by Alzheimer’s disease and related dementias nationwide. Each grant award is $6,000. Grants are awarded twice a year.

2026 application deadlines:

Spring Cycle-Friday, March 20, 2026 5:00pm EST

Fall Cycle-Friday, September 25, 2026 5:00pm EST

AI Based Application Success Predictor

1. Direct relevance to Alzheimer's disease and related dementias (highest predictor)

This is the strongest predictor.

Competitive proposals should focus on:

Alzheimer's disease
Mild cognitive impairment (MCI)
Lewy body dementia
Vascular dementia
Frontotemporal dementia
Mixed dementia
Other Alzheimer's-related dementias

Projects addressing unrelated neurological disorders generally fall outside AFA's mission.

2. Potential to improve patient care and quality of life (very high predictor)

AFA places exceptional emphasis on improving the lives of individuals living with dementia and their families.

Competitive projects should demonstrate potential to:

Improve diagnosis
Improve patient care
Enhance quality of life
Improve cognitive function
Reduce behavioral symptoms
Improve caregiver support
Delay disease progression

Patient-centered outcomes are a defining feature of AFA-supported research.

3. Innovation and scientific originality (very high predictor)

Competitive proposals often investigate:

Novel biomarkers
Digital health technologies
Early detection methods
Innovative care models
Lifestyle interventions
Non-pharmacologic therapies
New therapeutic targets

Projects should clearly explain how they address important unmet needs or advance current knowledge.

4. Strong scientific merit and rigorous methodology (very high predictor)

Successful applications generally include:

Clear hypotheses
Strong rationale
Appropriate study design
Robust statistical methods
Feasible recruitment strategy
Well-defined outcomes
Realistic milestones

Scientific rigor remains essential even for pilot or early-stage studies.

5. Early detection and prevention research (high predictor)

AFA strongly supports work aimed at:

Earlier diagnosis
Risk identification
Cognitive screening
Prevention strategies
Modifiable risk factors
Public awareness of dementia

Projects that improve early recognition or reduce future disease burden are well aligned with AFA's mission.

6. Early-career investigator development (high and distinctive predictor)

Historically, AFA has placed considerable emphasis on supporting promising early-career investigators.

Competitive applicants typically demonstrate:

Scientific promise
Commitment to dementia research
Early publication record
Strong mentorship
Potential for research independence

Career development is an important objective of many AFA-supported research initiatives.

7. Translational and clinical relevance (high predictor)

Competitive projects often bridge:

Laboratory discoveries
Clinical research
Behavioral interventions
Community implementation
Health services research

Research with a realistic path toward improving patient care is particularly competitive.

8. Caregiver and family-centered research (high and distinctive predictor)

One characteristic that distinguishes AFA from many biomedical funders is its strong interest in caregiver support.

Competitive studies may address:

Caregiver burden
Family education
Behavioral management
Care coordination
Psychosocial interventions
Community-based dementia care

Projects improving the well-being of caregivers are strongly aligned with the Foundation's broader mission.

9. Potential for future external funding (high predictor)

Because AFA research awards often function as seed funding, competitive proposals clearly explain how the project will:

Generate preliminary data
Lead to NIH funding
Support larger clinical studies
Establish long-term dementia research programs

Strong future funding potential enhances competitiveness.

10. Dissemination and impact on dementia care (high predictor)

Competitive projects should demonstrate potential to:

Publish results
Present at scientific meetings
Inform clinical guidelines
Improve community dementia care
Influence healthcare policy
Enhance public education

Research with broad dissemination potential aligns well with AFA's educational mission.

Specialties

Neurosciences

Eligibility Requirements

AFA funding is based on the premise that partnership and collaboration are the cornerstones of our efforts to achieve AFA 's mission to provide support, education and research towards Alzheimer's and other dementia related brain diseases in our communities. AFA recognizes the rights and authority of grantees, through their governing bodies, to determine their own policies and manage their own programs. As a result, AFA delineates the following grant conditions to be acknowledged by the grantee as part of their obligation upon acceptance of grant funding.

• Recognize AFA as a funder and partner on the agency website and social media with a link, listing and/or logo.

• As appropriate; a. Acknowledgment of AFA in annual report. b. AFA logo placement on funded program brochures, flyers and mailings.

• Grantee will 'like' AFA social media pages and 'like', 'follow', 'tag' and 'share' social media content where applicable.

• Grantee will provide AFA with a full color EPS or high resolution (l-2MB) JPEG of the agency logo to be emailed to Grants@alzfdn.org

• Grantee will agree to advocate for and positively represent AFA to the general public.

• Grantee will use AFA grant funding for the sole purpose of the specified program outlined in this application.

a. Allowable expenses include, but are not limited to:

1. Administrative expenses

2. Staff training

3. Staff salary (inclusive of payroll taxes and benefits) for staff involved in program implementation

4. Occupancy

5. Supplies and equipment b. Unallowable expenses include:

1. Costs that do not support or benefit the program, or are not necessary in carrying out the program

2. Salary increases as the single reason for increased request

3. Membership fees

4. Costs or expenses incurred outside the grant period

5. Expend grant funds not in accordance with the budget submitted, approved, and included as part of the submitted application

c. Communicate in writing to AFA, as early as possible, whenever changes which may affect the outcome of the program have occurred, including key staff changes.

Sponsor Details

Sponsor Institute/Organizations: Alzheimer's Foundation of America

Sponsor Type: Corporate/Non-Profit

Address: 322 Eighth Avenue, 16th Floor New York, NY 10001

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