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Addressing Health Outcomes for Individuals With Intellectual and Developmental Disabilities Topical PCORI Funding Announcement

Patient-Centered Outcomes Research Institute (PCORI)

The Patient-Centered Outcomes Research Institute (PCORI) is the nation’s leading funder of patientcentered comparative clinical effectiveness research (CER). By comparing two or more health or healthcare approaches, CER generates evidence that helps people make better-informed decisions and improves healthcare delivery and outcomes. PCORI takes a holistic approach to its work, ensuring that patients and other health decision makers are engaged as partners throughout the research process, supporting dissemination and implementation of results in practice, and strengthening clinical research infrastructure to advance patient-centered CER. PCORI is an independent, nonprofit organization authorized by Congress.

PCORI’s funding announcements align with PCORI’s National Priorities for Health as a means of ensuring applications address the health and healthcare challenges facing the nation today and in the years ahead. PCORI’s National Priorities for Health are a comprehensive set of mutually reinforcing goals that focuses on impact, and drive research funding and other initiatives to improve patient care and health outcomes. PCORI's Research Project Agenda comprises a set of Topic Themes that inform focused funding opportunities for patient-centered comparative clinical effectiveness research (CER) through a series of funding cycles. This set of Topic Themes evolves over time to promote PCORI funding across the full range of health issues and conditions faced by the U.S. population.

Key Dates Online System Opens: April 1, 2025

Town Hall: April 7, 2025, noon - 1 pm (ET)

Letter of Intent (LOI) Deadline: May 13, 2025, by 5 pm (ET)

LOI Status Notification: June 10, 2025

Application Deadline: September 3, 2025, by 5 pm (ET)

Merit Review: November 2025

Awards Announced: March 2026

Earliest Project Start Date: July 2026

Maximum Project Budget (Direct Costs) Up to $12 million At the time of contract execution, PCORI sets aside all the funds associated with an awarded project to be made available throughout the contract’s period of performance. The maximum budget includes all research- and peer-review-related costs

Funds Available up to Approximately $60 Million

AI Based Application Success Predictor

1. Strong patient-centeredness and stakeholder engagement (Highest Predictor ⭐⭐⭐⭐⭐)

This is the defining feature of PCORI funding.

Competitive proposals should demonstrate:

Meaningful engagement of patients throughout the project
Partnership with caregivers and clinicians
Involvement of healthcare stakeholders in study design
Shared decision-making throughout the research process

Patient and stakeholder engagement is a core review criterion and is expected from project conception through dissemination. (pcori.org)

2. High potential to improve healthcare decisions (Highest Predictor ⭐⭐⭐⭐⭐)

PCORI funds research that generates evidence patients and clinicians can use.

Competitive projects should:

Compare healthcare interventions
Address real-world clinical questions
Inform treatment decisions
Improve shared decision-making
Produce evidence useful for everyday practice

Research should clearly explain how it will improve healthcare choices rather than simply advance scientific knowledge. (pcori.org)

3. Scientific merit and methodological rigor (Highest Predictor ⭐⭐⭐⭐⭐)

Competitive proposals include:

Robust study design
Appropriate comparator groups
Rigorous statistical methods
High-quality data collection
Strong internal validity
Feasible implementation

PCORI expects studies to produce reliable evidence suitable for clinical decision-making. (pcori.org)

4. Comparative Clinical Effectiveness Research (CER) relevance (Highest Predictor ⭐⭐⭐⭐⭐)

A defining requirement for most PCORI funding opportunities is comparative effectiveness.

Competitive projects compare:

Two or more interventions
Diagnostic strategies
Treatment approaches
Healthcare delivery models
Prevention strategies

Studies should generate evidence about which option works best, for whom, and under what circumstances. (pcori.org)

5. Strong engagement plan throughout the research lifecycle (Very High Predictor ⭐⭐⭐⭐⭐)

Successful applications include:

Patient advisory panels
Stakeholder governance
Co-design of research questions
Ongoing engagement during implementation
Participation in interpretation and dissemination

PCORI evaluates whether engagement is authentic, continuous, and meaningful—not merely advisory. (pcori.org)

6. Potential for implementation and healthcare impact (Very High Predictor ⭐⭐⭐⭐⭐)

Competitive proposals demonstrate:

Practical applicability
Clinical relevance
Potential for adoption
Dissemination strategies
Health system impact
Improvements in patient outcomes

Research should be positioned to influence routine clinical practice and healthcare delivery. (pcori.org)

7. Diverse populations, health equity, and inclusion (Very High Predictor ⭐⭐⭐⭐⭐)

PCORI strongly encourages research involving:

Diverse populations
Underrepresented groups
Rural communities
Health equity
Social determinants of health
Inclusion across demographic groups

Projects addressing disparities in health outcomes are particularly competitive. (pcori.org)

8. Experienced multidisciplinary research team (High Predictor ⭐⭐⭐⭐☆)

Reviewers consider:

Investigator expertise
Clinical experience
Methodological expertise
Biostatistical support
Patient partners
Health system collaborators

Successful teams often include clinicians, researchers, patients, and implementation experts. (pcori.org)

9. Realistic project management and budget (High Predictor ⭐⭐⭐⭐☆)

Competitive proposals provide:

Well-justified budgets
Realistic timelines
Clear milestones
Efficient project management
Appropriate resource allocation

Budgets should be proportional to the project's complexity and scope. (pcori.org)

10. Strong dissemination and implementation strategy (High Predictor ⭐⭐⭐⭐☆)

Competitive applications describe how findings will be:

Shared with patients
Communicated to clinicians
Disseminated to health systems
Used by policymakers
Implemented into practice

PCORI places substantial emphasis on ensuring research findings reach the people who can use them.

Specialties

Clinical Trials

Technology Development

Eligibility Requirements

In general, applications for the conduct of research and management of funding may be submitted by appropriate academic research, private sector research, or study-conducting entities. This may include, among others, agencies and instrumentalities of the federal government, nonprofit and forprofit research organizations, and colleges and universities.

Per PCORI’s authorizing statute, every applicant must demonstrate capability to comply with the following conditions: abide by the transparency and conflicts of interest requirements that apply to PCORI with respect to the research managed or conducted under contract; comply with the PCORI Methodology Standards; consult, as appropriate, with the expert advisory panels for clinical trials and rare disease; deposit de-identified data from the original research into a PCORI-designated repository to facilitate data sharing, as appropriate; have appropriate processes in place to manage data privacy and meet ethical standards for the research; comply with the requirements of PCORI for making the information available to the public; and comply with other terms and conditions determined necessary by PCORI to carry out the research project. Potential applicants are strongly encouraged to review the standard research contract prior to application. Individuals are not permitted to apply. Foreign organizations and nondomestic components of U.S organizations must provide a thorough and thoughtful justification for the research's ability to benefit the U.S. healthcare system and that the engagement plans include U.S. patients and stakeholders and are relevant to the U.S. healthcare system.

Sponsor Details

Sponsor Institute/Organizations: Patient-Centered Outcomes Research Institute (PCORI)

Sponsor Type: Corporate/Non-Profit

Address: 1333 New Hampshire Ave NW, Suite 1200 Washington, DC 20036 Phone: 202-827-7700

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